Multitudes of Syrian Christians gathered for mass Sunday evening inside the Greek Orthodox Church of the Prophet Elias in Damascus — and dozens of them never returned home.

Their prayers were interrupted by a jihadist who opened fire on the faithful, then detonated an explosive vest, killing at least 25 Christians and wounding 63 others. The explosion reportedly caused extensive damage to the structure of the church.

This terrorist attack — yet another reminder of the unrelenting persecution of Christians worldwide — was supposedly executed by a member of ISIS.

Syrian President Ahmed al-Sharaa — the Islamic terrorist also known as Abu Mohammad al-Julani, who rose through the ranks of the Islamic State of Iraq before founding an Al-Qaeda affiliate in Syria, Jabhat al-Nusra — condemned the attack and expressed condolences, reported the state-owned network Alikhbaria Syria.

Al-Sharaa called the attack a "heinous crime" that serves as a reminder of the importance of solidarity and unity of the regime and people in the face of security threats.

Christian persecution watchdogs have warned in recent months that the al-Sharaa regime cannot be trusted. After all, the regime is largely composed of and led by elements of Hay'at Tahrir al-Sham, an Al-Qaeda spinoff terrorist organization linked in its formative years to the late leader of ISIS, Abu Bakr al-Baghdadi, and whose current leader was until recently a specially designated global terrorist who fought against American forces in Iraq.

Jeff King of International Christian Concern, for instance, noted after the reported massacre of Syrian Christians by regime-aligned jihadists in March that the government is "Al-Qaeda and ISIS in a new guise."

Despite his personal history with ISIS and Al-Qaeda, it is nevertheless in al-Sharaa's interest to respond forcefully to the attack, not only to remain on good terms with President Donald Trump — who vowed to "protect persecuted Christians" ahead of the 2024 election and whose administration lifted U.S. sanctions last month — but to counter the internal threat to his rule. After all, ISIS now regards the Hay'at Tahrir al-Sham-led regime as illegitimate.

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Photo by Ali Haj Suleiman/Getty Images

Al Jazeera reported that ISIS has repeatedly attacked government forces in recent months, labeling the government an "apostate regime."

Mazhar al-Wais, the Syrian minister of justice, called the bombing a "cowardly crime targeting the unity of Syrians," suggesting that al-Sharaa's regime would not tolerate terrorism.

A senior U.S. official told Blaze News, "This is just another reminder that global jihadists see innocent unarmed Christians as legitimate targets."

"The new government in Damascus will be measured in large part by its willingness to protect minorities and neutralize groups like ISIS," added the official.

Ever distrustful of the regime, the Syrian Network for Human Rights insisted Sunday that "protecting the crime scene at Mar Elias Church is a necessary first step toward establishing the truth and achieving accountability."

'People were praying safely under the eyes of God.'

The watchdog group suggested that extra to securing the site's perimeter and preventing unauthorized entry and tampering with evidence, it is essential that Syrian authorities "regulate the movement of personnel and media to ensure that only authorized forensic teams are allowed to work on site" and to "implement accurate documentation procedures."

The Greek Orthodox Patriarchate of Antioch said in the immediate wake of the attack, "The treacherous hand of evil struck this evening claiming our lives, along with the lives of our loved ones who fell today as martyrs during the evening Divine Liturgy at the Church of the Prophet Elias in Dweilaa, Damascus."

Ecumenical Patriarch of Constantinople Bartholomew I asked Patriarch John X, the primate of the Greek Orthodox Patriarchate of Antioch and All the East, to convey his heartfelt condolences and support to the families of the victims, and prayed to "the All-Good God to rest the souls of the innocent victims of the attack."

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US President Donald Trump meets with Syrian President Ahmed al-Sharaa (L) along with the Saudi Crown Prince Mohammed bin Salman Al Saud (R) on May 14, 2025. Photo by Bandar Al-Jaloud/Saudi Royal Court/Handout/Anadolu via Getty Images)

Witnesses indicated that when the suicide bomber entered the church and began firing, parishioners heroically charged him, reported the Associated Press. Once confronted, the masked terrorist detonated his vest.

"People were praying safely under the eyes of God," said Fr. Fadi Ghattas, who was present when at least 20 Christians were killed by the explosion. "There were 350 people praying at the church."

Issam Nasr, a witness who was praying inside the church, said he observed some victims get "blown to bits."

"We have never held a knife in our lives," said Nasr, underscoring the defenseless nature of the Christians targeted in Damascus. "All we ever carried were our prayers."

According to International Christian Concern, parish priest Fr. Youhanna Shehata assisted in carrying the remains of over 20 victims out of the church in the wake of the attack.

Blaze News reached out to the White House for comment but did not immediately receive a response.

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