Japan is close to finding cure for rare disorder that devastates children



A rare defect that can be devastating to children is getting a first-of-its-kind medicine from Japanese researchers.

A new treatment is now five years in the making, and after being used for medical applications, it's likely the product will be available for use by the general population as well.

'We feel that people's expectations ... are high.'

Since 2021, Japanese researchers have been hoping to find a solution for anodontia, the medical term for the complete absence of teeth, according to the Cleveland Clinic.

The initial study for this project states that anodontia and congenital tooth agenesis are common tooth anomalies affecting 1% of the worldwide population, resulting in a high rate of missing teeth.

The solution, according to lead researcher Katsu Takahashi, is to counteract a protein called USAG-1, which inhibits the growth of teeth.

"We want to do something to help those who are suffering from tooth loss or absence," he told the Mainichi in 2024. "While there has been no treatment to date providing a permanent cure, we feel that people's expectations for tooth growth are high."

The goal of the project is to give young children who have no teeth the joy of a real smile.

RELATED: Japan’s beautiful love affair with America

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The research was moved into human trials in October 2024 and lasted until October 2025. The controlled trial involved 30 males between 30 and 65 who were missing one or more molars, and the medicine was administered through one single intravenous dose.

The study has since been marked as completed, but little public information has been released. However, the Economic Times reported that as of April, preliminary analyses showed positive results with no significant side effects.

The next phase of the research is reportedly to test the medicine on children between 2 and 7 who suffer from congenital anodontia.

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- YouTube

The teams at Kitano Hospital and Kyoto University Hospital believe that it may be soon possible to grow teeth not only in people with the aforementioned conditions, but also for common conditions like tooth loss from cavities or injuries.

According to Popular Mechanics, if the latest trials are successful, the researchers believe the medicine will become available to the public for all forms of tooth loss around 2030.

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Guilty Reading Pleasure

If you are a bookish person, odds are that your running gift-list for family members, friends, colleagues, and so on includes other heavy readers. Among them may well be some who enjoy mysteries, "crime fiction," and the like. If that is indeed the case, I have a suggestion for you: Keigo Higashino’s novel Guilt, just published by Minotaur Press. You might want to get a copy for yourself as well.

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Prime Time for Japan’s War Minister

General Hideki Tojo served as Japan’s war minister (administrative leader of the Imperial Army) from July 18, 1940, to July 18, 1944, and then concurrently as prime minister from October 17, 1941, to July 18, 1944. As such, he is a central figure in the war, functionally parallel to Winston S. Churchill and Franklin D. Roosevelt. Despite his indisputably high standing among all World War II leaders, this outstanding work by Peter Mauch provides the first full English-language portrait of Tojo in a reader-friendly narrative based on formidable research and shrewd judgment.

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Japan’s beautiful love affair with America



For a brief moment, X stopped reading like a machine built to aggravate, divide, and degrade the people using it. Instead of the usual sludge of foreign bots and demoralizing propaganda, American users found themselves, thanks to a new auto-translation feature, staring at something unexpected: a flood of posts from Japan celebrating the United States. Monster trucks, backyard barbecue, Old West revolvers, bluegrass music, country songs, and all the rowdy symbols of American life that our own elites often treat as embarrassing were suddenly being admired from abroad.

It reminded Americans that our culture is not only real, but vivid enough that another people can see its beauty even when we have been taught to sneer at it ourselves. If Americans and Japanese are to continue to enjoy our distinct cultures, we must fight to maintain the true diversity that makes a civilization worth preserving.

Status in the U.S. and many other Western nations is acquired by looking down on the folkways of the average American.

Most Americans know that there is a strong current of appreciation for Japanese culture in the U.S. Americans eat Japanese food, watch anime, read manga, practice karate, and revere samurai movies. While we were once in a brutal war, Americans have come to respect the noble and beautiful traditions of the Japanese. What many Americans did not know is that the Japanese also have a robust subculture of appreciation for American culture.

Americans are constantly told that they have no culture, or that what they do have is shallow, vulgar, and unworthy of defense. In much of elite life, status comes from mocking the tastes and traditions of ordinary Americans. Status in the U.S. and many other Western nations is acquired by looking down on the folkways of the average American.

It is not just that the Japanese love American culture, but that they seem to focus specifically on rural Southern and Western archetypes. Banjos playing “Take Me Home, Country Roads," barbeques grilling comically large steaks, monster trucks crushing everything below them. The Japanese love and celebrate everything that American elites have trained the population at large to sneer at.

Recently, many people have been asking the question “What is an American?” But the Japanese seem to know right away. There is no confusion, no debate. The answer is obvious and plays itself out in the memes, re-enactments, and celebrations the Japanese enjoy while honoring American culture. Sometimes another people can identify your defining traits more clearly than you can, especially after your own institutions have spent years trying to dissolve them.

In a period when many people in the United States feel estranged from their own inheritance, it was oddly heartening to see ourselves reflected in a nation we admire. If the Japanese know who Americans are, then the least we can do is be proud to act like the Americans the Japanese love.

This sudden outburst of cultural appreciation also puts to bed the idea that Americans are xenophobes who hate other countries. Japan’s love for the U.S. is reciprocated with great fervor by Americans. But why are Americans so willing to appreciate and embrace the Japanese while being dismissive of so many other countries? The answer is simple: The Japanese are worthy of admiration. Not all cultures are equal, and the Japanese have emerged from the devastation of war to rebuild a high-trust society on a foundation of rich history and honorable conduct. It turns out that Americans don’t hate other cultures; they simply save their appreciation for those that deserve it.

The social media cultural exchange also highlighted the importance of real diversity and the need to protect distinct cultures. Both the Americans and Japanese hold reciprocal appreciation for each other’s civilizations and want to see them continue into the future. Americans want our grandchildren to be able to visit Japan in 100 years and experience what we celebrate now, and the Japanese feel the same about the U.S. An island called Japan that had the same borders and topography but was filled with Indians, Palestinians, and Somalians would not be the same. If the island chain of Japan were full of Haitians, it would not be Japan; it would be Haiti with some cherry blossoms.

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Blaze Media Illustration

That is the point that modern ideology cannot admit. A nation is not just a market, a legal zone, or a patch of land inside a set of borders. It is the Japanese people, their way of life, and the culture they create that define the nation. Japan has been better than most modern nations in protecting its identity, but the country is under immense pressure to open its borders. Like much of the modern world, Japan is experiencing a massive decline in birth rates and is struggling to care for its elderly population while replacing its workforce. After dabbling in increased immigration to bolster its workforce, the nation has elected a right-wing government to reimpose restrictions. A civilization can survive low birth rates for a time; it cannot survive replacement.

Americans are beginning to understand the same truth about themselves. If Japan would cease to be Japan after demographic replacement, then the United States would cease to be the United States under the same conditions. America is a real, distinct culture with traditions, folkways, and history that are worthy of pride. America is not just an economy or an administrative zone attached to a flag. We need to stop being shamed into rejecting our culture or treating it as the banal background for a global empire. Japan is beautiful because the Japanese have built a civilization worth preserving. America is beautiful because Americans built a distinct culture worth preserving. That culture deserves more than ironic detachment or ritual embarrassment. It deserves loyalty. The Japanese, in their odd and affectionate way, reminded Americans of something many had forgotten: This country is real, its inheritance is beautiful, and it is worth preserving.

America’s elites trusted global trade. Japan trusted reality.



“Moshitora,” Japanese shorthand for “what if Trump?,” first emerged in the run-up to the 2016 U.S. election, as policymakers and business leaders in Tokyo tried to make sense of an unpredictable candidate.

The phrase resurfaced in early 2024 as Donald Trump’s campaign regained momentum. This time, it carried more than curiosity. It reflected strategic caution and genuine unease. What would a second Trump presidency mean for Japan’s security, its economic ties, and its role in the Indo-Pacific?

The US-Japan alliance has entered a new phase that looks beyond defense alone.

The question mattered bigly. Since former Prime Minister Shinzo Abe’s assassination in 2022, Japan has had to manage its alliance with Washington without the personal rapport Abe cultivated over decades. Trump’s first term had already shown how quickly supply chains could become instruments of strategic power and how fast economic policy could merge with national security.

For decades after the Cold War, Western policymakers assumed deep trade ties would soften geopolitical tensions. If nations became economically intertwined, conflict would grow too costly to sustain. That assumption collapsed. Supply chains did not reduce rivalry. They became tools of leverage instead.

Technology, once treated mainly as an engine of economic growth, became a strategic asset. Materials long confined to commodity markets — lithium, cobalt, nickel, and rare earths — moved to the center of national security planning.

The consequences reached far beyond trade policy. Industries once taken for granted became strategic pressure points. Governments began to see commercial flows not as neutral exchanges, but as levers of power. Control over production, processing, and access could shape the balance of global influence.

Trump’s first administration accelerated that reckoning. Washington had to confront dependencies it had ignored for too long. Over the next several years, policymakers turned instinct into structure. Alliances no longer looked like military arrangements alone. They began to function as economic security networks built around trusted supply chains, resilient manufacturing, and reliable access to critical materials.

The results are now visible. In October 2025, the U.S. and Japan signed a framework to secure supply chains for rare earths and critical minerals, with the stated goal of reducing dependence on China’s dominant processing capacity.

Africa shows the stakes even more clearly. In early 2026, Glencore entered a nonbinding agreement with the U.S.-backed Orion Critical Mineral Consortium to sell 40% of its Mutanda and Kamoto copper and cobalt mines in the Democratic Republic of Congo.

RELATED: China is arming itself with minerals America refuses to mine

Bert van Dijk / Getty Images

These mines rank among the world’s largest producers of metals essential to next-generation technologies. The deal aims to diversify supply beyond China’s orbit.

Across Africa, Washington has deepened partnerships to strengthen supply chains for essential commodities, while Japan has pursued its own ties with resource-rich nations.

These efforts go beyond securing raw materials. They concern industrial resilience, strategic autonomy, and influence over the technologies that will define the next era of power. Countries now face a hard question: Who offers long-term commitment, and who merely shows up to extract what it needs?

Japan’s approach reflects foresight. Its economic security policies — diversifying supply chains, investing in semiconductors, and deepening ties with African and Southeast Asian resource producers — show a clear understanding that industrial capacity underwrites national power. In some respects, Tokyo saw this shift coming before Washington did.

The U.S.-Japan alliance has entered a new phase that looks beyond defense alone. Who will build together, mine together, and secure the industrial base behind technological competition? The choices nations make now will help determine which economies and militaries remain resilient enough to compete in the years ahead.

“Moshitora” began as a phrase about a single American election. Its return in 2024 looks, in hindsight, like a warning Japan had already begun to heed. The question now is whether Washington will answer with the same clarity, persistence, and long-term vision.

No Surprise: America Needs Our Allies More Than Ever

The world’s attention is fixed on the Strait of Hormuz, Iran’s determination to cripple the global economy, and Donald Trump’s attempts to break the energy blockade. But, as Japanese prime minister Sanae Takaichi’s White House visit this week demonstrates, the wheel of history continues its relentless turn in other strategically vital parts of the world too.

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Fixing Government Waste And Fraud Starts With Giving Power Back To States

The founders would be astonished to know the federal government now regulates education, health care, finance, energy, and practically every business in America.

What History Tells Us About Trump’s Plan To Defeat Iran By Air

President Donald Trump called for Iran’s “unconditional surrender” on March 6. But can he do that with U.S. air power alone? The answer is likely yes — if the Iranian people themselves are also the “boots on the ground.” Air power advocates have promised decisive results since the Italian general Giulio Douhet authored “The Command […]

Behind Japan’s pacifism hides a nuclear escape hatch



Japan transformed from an expansionist military power to a pacifist state within a decade after World War II, adopting a firmly non-nuclear posture after suffering atomic bombings on Hiroshima and Nagasaki. Yet Japan possesses one of the most advanced civilian nuclear infrastructures in the world, technically capable of creating nuclear weapons.

As debates in the United States intensify over alliance commitments and burden-sharing, questions about the credibility of America’s extended deterrence are growing. If that credibility weakens, Japan may find itself increasingly alone in deterring China, North Korea, and Russia.

As Japan becomes more militarized, nuclear pacifism may begin to be replaced with nuclear realism.

Japan is already reinterpreting elements of its postwar restraint, evident in the modernization of the Japan Self-Defense Forces and the acquisition of long-range counterstrike capabilities for “deterrence by punishment.” Will Japan do the same with nuclear weapons?

The nuclear threshold is near

Japan lacks nuclear warhead expertise, dedicated delivery systems, and secure nuclear testing infrastructure, but it does have the industrial, material, and financial resources to begin a nuclear weapons program.

Japan possesses full-scale nuclear fuel cycle facilities, accumulating over 45 metric tons of separated plutonium, enough to make thousands of nuclear weapons. Japan is projected to increase reliance on fast breeder reactors; these reactors produce more plutonium than they consume.

Japan is also building facilities that eliminate the need to outsource its spent fuel for reprocessing, allowing Japan to domestically produce separated plutonium. Some analysts estimate that Japan could develop a small nuclear arsenal within a year.

Despite Japan’s nuclear latency, it has not crossed the nuclear threshold. Other than public consensus and constitutional restraints, Japan is held back by technical and financial costs. Japan needs to develop nuclear weapons design expertise, delivery systems, and secure infrastructure, all financially and politically costly endeavors.

Furthermore, Japan’s civilian nuclear facilities operate under International Atomic Energy Agency safeguards. That makes it difficult to run a clandestine nuclear weapons program. While the costs are substantial, they are not prohibitive for a country with Japan’s industrial and technological capacity. Given its advanced nuclear power program and infrastructure and increasingly sophisticated military, Japan can develop the technical requirements for a nuclear weapons program in short order.

Hedging nuclear bets

Japan is a nuclear latent power, so the central issue is intent. Japan adopted what strategists call “insurance hedging,” entailing a cost-benefit analysis of U.S. extended deterrence to determine whether relying on U.S. nuclear weapons is worth the risk of Japan not having its own. Should U.S. extended deterrence fail or be perceived as too weak, Japan will claim insurance by developing nuclear weapons for its own protection.

Japan became an insurance hedger for two reasons: It wants the option to develop nuclear weapons and does not want to forgo U.S. extended deterrence. Japan relies on U.S. extended deterrence for security, but pursuing nuclear weapons could remove Japan from America’s nuclear umbrella.

RELATED: Trump’s Iran gamble: Peace Prize or Persian Gulf firestorm

Photo by Tajh Payne/US Navy via Getty Images

Insurance hedging allows Japan to stay within U.S. extended deterrence while preparing for the possibility of abandonment or failure by the United States. Nuclear latency serves as leverage. If U.S. security guarantees weaken, Japan would retain the ability to respond independently.

Nuclear latency was always the plan

Japan’s nuclear latency is not an accident. As early as the 1950s, Japan deliberately preserved nuclear latency while relying on the United States for deterrence. Japan understood the deterrence value of nuclear weapons, especially in a security environment surrounded by nuclear powers and potential nuclear powers.

For Japan, the United States would serve as its nuclear deterrent, which allowed Japan to maintain its pacifist posture. Nuclear pacifism is still dominant in Japanese strategic culture, but as Japan becomes more militarized, nuclear pacifism may begin to be replaced with nuclear realism.

If U.S. extended deterrence no longer offers Japan the protection it needs, and domestic consensus against nuclear weapons is resolved, Japan could shift in favor of nuclear weapons. To create the JSDF, Japan reinterpreted Article 9 of the Japanese Constitution; Article 9 is an explicit “Renunciation of War” mandating that Japan never maintain “war potential.” Japan once reinterpreted Article 9 to build the Self-Defense Forces. Reinterpreting nuclear pacifism would be far more controversial, but not unprecedented.

Editor's note: This article was originally published by RealClearDefense and made available via RealClearWire.

Japan’s Iron Lady Won’t Go Wobbly Against China

In the land that introduced the world to Godzilla, a new giant has arisen. The Liberal Democratic Party's landslide victory in Japan's lower house elections on Sunday gave Prime Minister Sanae Takaichi the largest majority of any party in 80 years. So many party members won their districts outright that the LDP has to find extra candidates to fill the seats that are awarded based on percentage of the national vote.

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