Chinese scientists produce fluorescent-green 'chimeric monkey' that glows



Chinese scientists continue to meddle with animal genetics, undeterred by recent internationally consequential mishaps. Rather than create another chimeric virus, a team from the Chinese Academy of Science has instead created a chimeric monkey with an eerie glow.

Researchers published their findings in the experimental biology journal Cell on Thursday, revealing that they had produced a substantially "chimeric monkey" with luminous fingertips and fluorescent green eyes.

The significance of the experiment was not the short-lived creature's nightclub features, but rather what the green luminescence signified: It was the most chimeric live primate produced to date, using the stem cells of two different fertilized eggs from the same species.

In other words the monkey, a long-tailed macaque, had two sets of DNA deriving from more than one set of parents.

Researchers cultured nine stem cell lines using cells extracted from a week-old monkey embryo and altered them to ensure that they were pluripotent — able to differentiate into all the cells necessary to create a live animal. The scientists then introduced a fluorescent green protein to the stem cells in order to track which tissues had derived from these lines.

These stem cells were injected into monkey embryos, which were in turn implanted into female macaques, resulting in 12 pregnancies and six live births. Of these, one live-born monkey and one miscarried monkey were found to be substantially chimeric.

The chimerical nature of the monkey that briefly survived outside the womb was evidenced by the green stain found in the various cells and tissue throughout its body, including in its brain, heart, kidneys, testicles, and gut.

Whereas in previous studies, chimeric monkeys have contained limited donor cell contributions to between 0.1% and 4.5% of their tissues, the range this time was from a low of 21% all the way up to 92%, representing a major breakthrough.

The chimera didn't glow for long. After 10 days, the macaque's health "deteriorated with respiratory failure and hypothermia, and it was euthanized by a veterinarian."

The apparent breakthrough could reportedly pave the way for the generation of animals with specific human-like characteristics tailored to the testing of medicines and drugs.

"This is a long-sought goal in the field," said senior author Zhen Liu, reported EurekaAlert.

"This research not only has implications for understanding naive pluripotency in other primates, including humans, but it also has relevant practical implications for genetic engineering and species conservation," continued Zhen. "Specifically, this work could help us to generate more precise monkey models for studying neurological diseases as well as for other biomedicine studies."

Study coauthor Miguel Esteban, principal investigator at the Guangzhou Institute of Biomedicine and Health, told CNN, "It is encouraging that our live birth monkey chimera had a big contribution (of stem cells) to the brain, suggesting that indeed this approach should be valuable for modeling neurodegenerative diseases."

"Monkey chimeras also have potential enormous value for species conservation if they could be achieved between two types of nonhumanprimate species, one of which is endangered," added Esteban. "If there is contribution of the donor cells from the endangered species to the germ line, one could envisage that through breeding animals of these species could be produced."

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Belgium introduces compulsory monkeypox quarantines as its spread continues to baffle global leaders



Belgium has become the first country to introduce a compulsory quarantine for people diagnosed with monkeypox, as the disease continues to spread seemingly randomly across the globe.

Belgian health authorities said that if they are diagnosed with monkeypox, Belgian residents will be required to self-isolate for 21 days, the Daily Mail reported.

Belgium recorded its first infection of monkeypox this past Friday, and it is believed that all subsequent cases are connected to a festival that was held in the port city of Antwerp.

The Belgian quarantine policy comes as European doctors have warned that Great Britain is facing a “significant” rise in monkeypox infections and that the British government’s response is “critical” in containing the spread.

This past weekend, 11 British residents tested positive for the virus, bringing the country’s total up to 20. The infected include a child who is currently in critical condition in a London hospital.

There are currently 100 recorded infections in Europe.

Suggesting that the disease might be spreading through sexual transmission, Dr. Claire Dewsnap, the president of the British Association for Sexual Health and HIV, said that the recent monkeypox outbreak could have a “massive impact” on access to sexual health services in the United Kingdom.

Dr. Susan Hopkins, a chief medical adviser to the U.K. Health Security Agency, also warned that monkeypox is spreading through community transmission.

Dewsnap recently said that “[Britain’s] response is really critical here. There is going to be more diagnoses over the next week.”

She said, “How many is hard to say. What worries me the most is there are infections across Europe, so this has already spread. It’s already circulating in the general population. Getting on top of all those people’s contacts is a massive job.”

Dewsnap suggested that case numbers could greatly increase in the coming weeks. She said, “It could be really significant numbers over the next two or three weeks.”

President Joe Biden is also concerned about the growing case numbers of monkeypox.

This past weekend, just before he left South Korea, Biden said, “Everybody should be concerned about it.”

He said, “We’re working on it, hard to figure out what we do.”

Adam Corolla suggests people only listen to AOC because she's attractive



Comedian and podcaster Adam Carolla just flicked an internet's hornet's nest. During an episode of "Hannity," Carolla suggested the reason Democrats and the rest of us pay so much attention to the sayings and doings of Alexandria Ocasio-Cortez is largely due to her youthful good looks.

Video:

\u201cIf AOC was fat and in her sixties, would anyone listen to another thing she ever said\u201dpic.twitter.com/jfK0v6VglV
— Acyn (@Acyn) 1643942331

"Here’s a quick thought experiment: If AOC was fat and in her sixties, would anyone listen to another thing she ever said?”

That caused Sean Hannity to throw a metaphorical life preserve to Carolla, saying he wasn't sure he agreed with Carolla's assessment, and argued that yes her ideas were out there (like the Green New Deal), but that AOC has so much influence she was a bit of a de facto leader of the Democrat party, having more power than Nancy Pelosi.

Throwing caution to the wind, Carolla pushed aside the metaphorical life preserve and concluded that he agreed with Hannity, but if AOC "was a middle-aged, heavyset woman, would anyone care what she had to say."

Whether or not Adam Carolla feels the same about Hilary Clinton, that's yet to be seen or heard.

Quick to react since reacting quickly is what it does best, the mobs of Twitter had words. Not all of them are dripping politeness.

Adam Carolla on Hannity proving AOC correct.pic.twitter.com/psukcGb6cM
— Monkey Chunk (@Monkey Chunk) 1643945937
Hannity wanted to say \u201cattractive\u201d and then his whiteness held him back.
— Outspoken\u2122\ufe0f (@Outspoken\u2122\ufe0f) 1643946054


I had words: if Adam Carolla were thin, good-looking and young, he would still be a flaming asshole.https://twitter.com/CheriJacobus/status/1489440283787935751\u00a0\u2026
— Norman Ornstein (@Norman Ornstein) 1643945308


Adam Carolla is an unattractive, unfunny middle aged jerk.https://twitter.com/RonFilipkowski/status/1489432510283096064\u00a0\u2026
— DrDinD \ud83c\udf0a\ud83c\udf0a\ud83c\udf0a\ud83c\udf0a\ud83c\udf0a (@DrDinD \ud83c\udf0a\ud83c\udf0a\ud83c\udf0a\ud83c\udf0a\ud83c\udf0a) 1643952686