How to renew American scientific research



For 80 years, American science has operated under the Vannevar Bush model that was established in the wake of World War II. In his 1945 report, "Science, the Endless Frontier," Bush argued that the government should fund “curiosity-driven basic research,” with panels of peer scientists choosing which projects deserved financial support.

His goal was not merely to subsidize scientists’ intellectual whims without regard for visible applications, but to secure American technological supremacy by developing fundamental knowledge before its practical uses were apparent.

In practice, however, Bush’s vision mutated into a bloated, risk-averse bureaucracy split between government and universities, stifling the very innovation it was designed to foster.

By funding researchers directly with stable, modest support, we can recreate the fertile conditions that historically produced revolutionary advances.

After eight decades, the weaknesses of Bush’s project-grant model are clear. As the White House Office of Science and Technology Policy points out in its new report, academic researchers spend up to half their time writing, formatting, and defending grant proposals rather than actually doing science. Moreover, because review panels naturally gravitate toward proven concepts, researchers are incentivized to propose incremental work that is guaranteed to succeed, often because they have already accomplished it.

The human cost of Bush’s model is staggering. The average age of a researcher receiving his first major independent grant from the National Institutes of Health has crept into the mid-40s — as the report notes, that is older than the average age of recent Nobel Prize winners when they made their breakthrough contributions.

We are forcing the brightest minds of academic science to spend their most creative decades acting as junior collaborators to insiders. The result is steady incremental progress, at least according to peers, but none of the breakthroughs that define true scientific revolutions.

Indeed, the OSTP is arguably much too kind to Vannevar Bush’s scheme: As the careful reader of the report may realize, the technological and scientific progress that powered the American century was produced almost entirely by alternative models based on missions set by the political leadership and their politically accountable deputies.

I propose a fundamental change in how we cultivate intellectual capital. We should largely zero out the current project-grant system for basic research and replace it with a radically simpler philosophy for supporting unguided curiosity: fund people, not projects.

Although the recent OSTP report accurately identifies the bureaucratic rot and systemic sclerosis within our current grant-making framework, we must extend its logic to its necessary conclusion. The report correctly asserts that federal science funding must be politically accountable; in a democracy, the public’s resources must be directed toward the public’s interests by those the people actually elect.

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Adam Glanzman/Bloomberg/Getty Images

To realize this ambition, Congress should circumvent this ossified establishment with a bold “metascience” pilot: 535 10-year research fellowships — one formally appointed by every member of the House and Senate. This gives lawmakers direct buy-in. It also dismantles the peer-review cartel, replacing the sterile consensus of risk-averse panels with the robust, structural accountability that the OSTP now recognizes as essential.

These fellowships would be awarded sequentially over a five-year rollout period, amounting to 107 new fellowships per year. Each selected fellow would receive a competitive, stable salary alongside modest lab support — say, capped at 100% of the salary — and would be placed with program help at an institution after winning, much the way Rhodes Scholarship winners are placed at an Oxford college.

This funding intentionally excludes substantial infrastructure, which would be funded through mission- or goal-based schemes.

The 10-year horizon of these fellowships is essential. Under the current three-year grant cycle, scientists must immediately begin worrying about their next funding application the moment their current one is approved. A decade of guaranteed support provides the freedom to take on the biggest and most fundamental problems and pursue unexpected insights.

The Howard Hughes Medical Institute, which funds researchers with grants of $10 million over seven years, bets on people rather than projects. It has produced a higher proportion of innovative, high-impact research by a wider margin than the project-based approach. Similarly, the OSTP report notes that the long-running NSF Graduate Research Fellowship Program, which funds students independently of their advisers and institutions, has produced over 40 Nobel laureates.

The selection mechanism must bypass the ossified academic science establishment. Recent Ph.D. graduates (or equivalent independent researchers) would submit their theses and publications, along with a brief vision statement, directly to a joint House-Senate committee. Committee staff, drawing freely on outside experts and advanced analytical tools, would rank the candidates. To guide this process, the committee would set rotating annual priorities.

The actual appointments would be assigned by a randomized lottery tied to congressional seats. When a member’s turn arises, he can either select a qualified applicant he believes in, or he can accept the top staff-recommended name from the staff-ranked list for that year.

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DNY59/Getty Images

While most members would likely defer to the staff ranking, letting them pick fellows if they want avoids inbreeding, gives politicians buy-in, and replicates the highly successful system of congressional nominations to military service academies. For the sake of scope and efficiency, this fellowship scheme centralizes the ranking of candidates at the committee level.

High-capital “big science” fields would continue to be funded directly by their institutional customers, such as mission agencies, the Department of Defense, or private industry. Small goal- or mission-oriented projects would be funded through a wide variety of models, along the many lines proposed in the OSTP report. The congressional fellowships are exclusively for the independent thinkers with the greatest apparent potential — the future Einsteins.

By funding researchers directly with stable, modest support, we can recreate the fertile conditions that historically produced revolutionary advances.

I estimate the cost of this pilot program during its rollout phase at roughly $35 to $40 million per year for the 107 new fellows, with modest administrative overhead. In the context of a federal research budget in the tens of billions, this is a tiny fraction of what we currently spend on the peers’ preferred marginal projects and their administration.

After five years, once all 535 fellowships are awarded, Congress can assess the program, as it should assess all research funding programs, before deciding whether to renew, modify, or expand it.

It is time to move beyond the bureaucratic legacy of the Bush model of peer review and project-based funding. The congressional fellowships would identify the most promising researchers of their generation and give them the freedom and time to think instead of writing grants. To advance Vannevar Bush’s endless frontier, we need simpler, more humane, and more exciting approaches to American innovation.

Editor’s note: This article was originally published at the American Mind.

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Gain-of-function experiments on hantaviruses? Yes, but virus threat is still MASSIVELY overblown.



The legacy media feverishly concern-mongered about COVID-19 and then tried unsuccessfully to generate similar hysteria over the gay-spread monkeypox virus.

Clearly desperate for a new health scare — especially after America formally rejected the World Health Organization — outlets seized upon reports of a deadly outbreak of hantavirus last month among passengers and crew of the MV Hondius, a Dutch cruise ship carrying 147 souls embarking from the southern tip of the Andes mountains in South America to the Canary Islands off the coast of Morocco.

'We should shy away from making bold pronouncements that may prove dangerously misleading weeks or months later.'

While some publications rushed to attack emerging theories about the nature of the virus, including the notion that it was cooked up in a lab — narrative attacks that neglected to mention a recent gain-of function experiment involving hantaviruses — others pushed alarmist headlines such as:

  • “Is hantavirus the next COVID? Is the U.S. response on point? An outbreak update” — NPR
  • “Why hantavirus is giving us a 'sinking feeling,' despite experts' reassurance” — Canadian state media
  • “Fears rat virus has spread to seven countries” — The Telegraph
  • “Could human-transmitted hantavirus be the next pandemic threat?” — The Week
  • “Hantavirus: Many unknowns surround an 'unprecedented and worrying' outbreak” — Le Monde

Despite provocative headlines and framing, many media outfits and experts have acknowledged that it is extremely unlikely that there will be a hantavirus epidemic, let alone a pandemic — though a news article at CNN cautioned against “calm-mongering” over hantavirus lest “post-COVID anxiety” be triggered.

A new article in the International Journal of Infectious Diseases, for instance, emphasized that while the suspected variety of hantavirus on the MV Hondius “can cause severe disease, high case fatality, and intense public anxiety when they emerge in mobile or closed settings,” such “outbreaks are not frequent” and are “unlikely to become a global outbreak.”

Hantavirus is a family of potentially deadly single-stranded RNA viruses that are naturally found in rodents. Only 890 cases of hantavirus were reported in the U.S. between 1993 and 2023, 35% of them fatal.

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The MV Hondius. Omar Havana/Getty Images

When spread to humans, hantaviruses can cause two diseases: hemorrhagic fever with renal syndrome — a condition affecting the kidneys — and hantavirus pulmonary syndrome, which affects the lungs.

The hantavirus affecting people on the MV Hondius, the HPS-associated Andes strain, is unique.

Whereas other strains leap from rodents to humans, the Andes virus — symptoms of which appear anywhere from four to 42 days after exposure — has been reported to transmit from person to person via saliva droplets and other oral fluids, although this transmission theory has not been definitively proven.

The breakout on the cruise ship, which has so far claimed the lives of three people, is hardly unprecedented in terms of alleged mass human transmissions of the disease — at least where South America is concerned.

From November 2018 through February 2019 in Chubut Province, Argentina, there was, for instance, a person-to-person outbreak that resulted in 34 confirmed infections and 11 deaths.

Amid continued uncertainty over the genesis of the latest outbreak and media fearmongering, a wide range of theories have emerged about the rodent-borne virus.

Having heard for years about the various efforts to enhance the transmissibility, virulence, or host range of certain viruses, some have speculated that human-to-human transmission of hantavirus points to gain-of-function experimentation.

While there’s been nothing yet to suggest that the virus responsible for the breakout on the Hondius was the result of intentional genetic meddling, scientists have previously modified viruses incorporating hantavirus components and increased their viral fitness in a lab setting. This is similar to the controversial work done on bat coronaviruses at the lab in Wuhan, China.

Hantaviruses are considered a bioagent requiring Biosafety Level 3 containment for research and viral propagation. Consequently, BSL-2 laboratories won’t cut it.

However, a peer-reviewed study funded by the National Institutes of Health and published in 2019 by the American Society for Microbiology describes how researchers developed a work-around for conducting hantavirus research in a lower biocontainment-security BSL-2 laboratory.

Researchers tried to make a safer chimeric virus — which is a hybrid virus created by piecing together parts of two different viruses. They used a relatively weaker virus, vesicular stomatis virus, as the main body, and then attached the entry proteins from the more dangerous hantavirus to the outside so that it could infiltrate and infect cells.

This new recombinant virus — the result of an artificial mash-up of genetic material — apparently started acting just like a real hantavirus and underwent a series of mutations to become more infective:

Serial passage of the rescued rVSV-HTNV Gn/Gc virus markedly increased its infectivity and capacity for cell-to-cell spread. This gain in viral fitness was associated with the acquisition of two point mutations: I532K in the cytoplasmic tail of Gn and S1094L in the membrane-proximal stem of Gc. Follow-up experiments with rVSVs and single-cycle VSV pseudotypes confirmed these results. Mechanistic studies revealed that both mutations were determinative and contributed to viral infectivity in a synergistic manner.

The lead researcher on the 2019 study declined Blaze News' request for comment.

This study is anything but a smoking gun. Whereas the COVID-19 pandemic appears to have originated in the neighborhood of the Wuhan Institute of Virology, where dangerous gain-of-function experiments were being conducted on coronaviruses, the Hondius outbreak seemingly took place a world away from this ostensibly low-danger hantavirus study.

Still, researchers have yet to provide a comprehensive and satisfying explanation for how the Andes virus spreads, prompting speculation that members of the scientific community that possibly manufactured the SARS-COV-2 virus are again not being entirely forthright about what they know and don’t know regarding the Hondius outbreak.

“Public health officials have to be more honest and more humble about how this virus actually spreads,” noted Joseph Allen, professor of exposure assessment science at the Harvard T.H. Chan School of Public Health. “An essential lesson from COVID is that officials should be candid about communicating that we are often learning in real time, and we should shy away from making bold pronouncements that may prove dangerously misleading weeks or months later.”

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In a recent interview, President Trump defended his earlier claim that bringing 600,000 Chinese college students into the United States would be good for the country. When the interviewer questioned how that aligned with an America First agenda, Trump replied that without those students, “Half the colleges in America would go out of business.”

To most Trump supporters, that sounds like a win-win — fewer foreign students and fewer left-wing universities to subsidize. But Trump seemed to view the issue as a business transaction: Closing locations is bad, losing revenue is bad, and the substance of those “economic units” doesn’t really matter.

Why should we play Russian roulette with our national security to pad universities’ bottom lines?

His comments revealed a deeper confusion about what America First really means.

The China contradiction

America’s relationship with China has long been incoherent. Every Republican politician insists China is our chief geopolitical rival — a totalitarian power bent on unseating the United States as global hegemon. Yet few make any effort to restrict Chinese immigration, investment, or influence. At some point, it becomes difficult to take any of the rhetoric seriously.

The problem is obvious: China has too many people and too much money. The country’s strength lies in what America abandoned: manufacturing. While American corporations chased financial gimmicks and “service economies,” China focused on making tangible goods at scale. That discipline built a vast middle class and positioned Beijing at the center of global production. Now nearly every Western industry — film, retail, education — depends on access to China’s markets.

The result: American institutions bend over backward to please a government they claim to fear. Chinese nationals can buy land, start companies, and enroll by the hundreds of thousands in U.S. universities. It would be funny if it weren’t so corrupt.

The university addiction

Trump knows mass immigration hurts Americans, but he struggles to say no when big money is involved. Foreign students pour billions into universities, and administrators have built their entire business models around them. But counting up dollars isn’t the same as serving the national interest.

Universities are publicly subsidized and supposedly dedicated to educating Americans first and foremost. Instead, they’ve turned into pipelines credentialing foreign elites — and sometimes, spies. Every seat filled by a Chinese student is one less for an American, and every dollar that props up a hostile regime’s protégés deepens our dependence on that regime.

The Department of Justice has charged three Chinese nationals at the University of Michigan for smuggling research materials and stealing technology. Eric Weinstein has even suggested that theoretical physics is being throttled for fear of espionage. Yet the universities — and now, apparently, Trump — seem unfazed.

Why save the enemy’s seminary?

Propping up higher education with Chinese cash isn’t just shortsighted — it’s insane. Colleges and universities have become leftist seminaries, charging astronomical tuition for courses that teach Americans to despise their parents and their nation. They already receive lavish government subsidies and still demand more.

Trump’s claim that “half the colleges” would collapse without Chinese money is dubious, but if it were true, those institutions deserve to fail. Let them. Destroying the patronage networks that produce radical activists was once a Trumpian goal. Reviving them with foreign money would be an act of political masochism. Why should we play Russian roulette with our national security to pad their bottom line?

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Stefani Reynolds/Bloomberg via Getty Images

The broader threat

Chinese money poisons more than academia. Nationals and shell companies routinely buy American land — including, alarmingly, property near military bases. One recent purchase of an RV park in Missouri by a Chinese couple just happened to place them next to Whiteman Air Force Base, home of the B-2 stealth bomber fleet. Similar shadowy transactions dot the map.

The pandemic exposed the madness of this dependence. The same regime that unleashed a virus on the world also controlled the supply chains for the medicine and protective gear we needed to fight it. Yet America’s political class still refuses to sever the tie. They are too addicted to Chinese money — and too invested in pretending that dependency equals diplomacy.

If the GOP is serious about confronting China, it must start by cutting every cord of reliance. Banning Chinese students from U.S. universities would be a simple, symbolic first step — and it would strike directly at the heart of the progressive academic machine.